DES and cardiomyopathy, familial restrictive, 1: This disease is mainly caused by the accumulation of desmin and collagen type 3, and the genes affected with the familial type of RCM include troponin (cTn), myosin light chain (MYL), desmin (DES), myosin binding protein (MyBP), myopalladin (MYPN), and TNNI3 [41].