MAPT and Alzheimer disease: The “core” AD neurodegenerative processes (β-amyloid oligomers and fibrils in plaques, and accumulation of hyperphosphorylated tau in neurofibrillary tangles) [16] are directly modulated by VPA [61], fluoxetine [106,107], escitalopram [109], propranolol [125], candesartan [167,173,174], and NSAIDs [241,242,243,244].