POU5F1 and osteosarcoma: Other authors showed that the inhibition of TNIK (an essential factor for the transactivation of Wnt signal target genes) with NCB-0846 decreased the expression of stem cell genes (SOX2, NANOG, OCT4, MYC) and ALDH activity and also favored lipid biosynthesis, driving osteosarcoma cells’ differentiation into adipocyte-like cells, via induction of PPARγ [139].