LDHA and osteosarcoma: Other studies also suggest that microRNAs may negatively regulate the expression of ALDH family members, such as miR-487b-3p and ALDH1A3, in vitro and in clinical samples [110], and miR-761 and ALDH1B1, in vitro and in vivo [111], which altogether substantiates the complex participation of ALDHs in the phenotypic behavior of osteosarcoma cells.