(2) Even in those TLR4 high-expressing PC cells (e.g., BxPC-3), up to 50% of the endogenous ligands-induced cell migration appeared to be uninfluenced by TLR4 knockout (Figure 4B), suggesting involvements of other pathways, possibly HGF/c-MET [26] and CD44 [27], which are well known to play important roles in cancer metastasis. The gene discussed is TLR4; the disease is cancer.