Despite the findings mentioned above, more questions emerged and await answers: (1) TLR4 was identified as the receptor that exclusively mediates PAUF’s migration-promoting effects, but the receptors that mediate PAUF’s other tumor-promoting effects still remain unclear (e.g., PAUF’s proliferation-promoting effects via the Wnt/β-catenin pathway [13]). The gene discussed is TLR4; the disease is neoplasm.