Considering the pleiotropic effects of TGF-β1 on cell proliferation, death, and division of various forms of liver cells, its capacity to induce EMT in epithelial cells or end EMT in endothelial cells and its potential to function as an immune modulator requires a deeper understanding to develop an effective therapy for targeting the TGF-β1 pathway in liver diseases considering its complex role in the liver [34,35]. The gene discussed is TGFB1; the disease is liver disorder.