Interestingly, when the authors compared biopsies from patients who received FSME-stimulated pDCs [29] with those from patients who received GM-CSF-stimulated cDC2s [83], a stronger infiltration of CD8+ T cells was detected in patients vaccinated with pDCs, but tumor antigen-specific CD8+ T cells were only found in patients who had received cDC2 [20]. This evidence concerns the gene CD8A and neoplasm.