The generation of a cell-permeable mimetic peptide of the GluN2B-PSD95 PDZ domain, known as NA-1 (also known as TAT-NR2B9C), that was designed to reduce coupling of nNOS to GluN2B via PSD95 produced a lot of optimism owing to its neuroprotective effects in stroke models in rodents and monkeys [91,95]. The gene discussed is GRIN2B; the disease is Stroke.