PNPLA3 and coronary artery disorder: One of the examples may be a polymorphism in the patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) genes that are related to an increased risk of exacerbating MAFLD occurrence [22], whereas they are not correlated with the development of coronary heart disease [23].