In this study, we found that (i) topical application of CAPCS ameliorated DNFB-induced AD-like skin lesions and reduced scratching behavior in BALB/c mice; (ii) CAPCS suppressed the infiltration of inflammatory cells and inhibited the expression of inflammatory cytokines in DNFB-induced AD-like skin lesions; (iii) CAPCS suppressed DNFB-induced serum levels of inflammatory cytokines; and (iv) CAPCS inhibited TLR2 and TLR4 protein expression in the skin lesions of BALB/c mice. Here, TLR2 is linked to Alzheimer disease.