In our study, we found that expression of IFN-γ (Th1 cell cytokine), IL-4, IL-5, IL-13, IL-31 (Th2 cell cytokines), IL-17, and IL-22 (Th17 and Th22 cell cytokines) were increased in both plasma and AD-like skin lesions of DNFB treated mice. The gene discussed is IL13; the disease is Alzheimer disease.