The expression of inflammatory cytokines, including IFN-γ, IL-4, IL-5, IL-13, IL-31, IL-17, and IL-22, was significantly increased in DNFB-induced AD-like dorsal skin lesions of the DT, DVT, DCT, and DDT groups, in comparison to normal dorsal skin in the NT group. Here, IL4 is linked to Alzheimer disease.