Taken together, as the present study demonstrated a similar profile of expression for miR-151a-3p and miR-199a-3p, their downregulation in the early-onset lymphedema in BCRL group may regulate major diabetic-related pathways such as insulin resistance, PI3K/Akt signalling, MAPK signalling pathway, mTOR signalling, and phospholipase D signalling. Here, INS is linked to lymphedema.