ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In conclusion, findings from the present study have demonstrated that secondary lymphedema in breast cancer survivors showed an association with metabolic syndrome features including obesity, hypertension, and diabetes mellitus, as indicated by the circulating miRNA (miR-199a-3p, miR-151a-3p) and adipokine (leptin, adiponectin) analysis.