Additionally, sphingolipid and phospholipase D signalling, insulin resistance, dilated cardiomyopathy, cyclic guanosine monophosphate-protein kinase G (GMP-PKG) signalling, and hyperthrophic cardiomyopathy underscore the involvement of metabolic diseases that are predominant in subjects of the lymphedema group (Table 4 and Supplementary Table S4). This evidence concerns the gene INS and lymphedema.