TARDBP and amyotrophic lateral sclerosis: The fact that differentiated motor neuronal cells show a different response to stress compared to immortalized cells is also supported by a recent study showing that TDP-43 did not form aggregates after acute oxidative stress (0.5 mM SA 0.5 h), but TDP-43 was recruited into SGs after long-term stress (10 μM SA 24 h) in C9ORF72 and TDP-43 ALS iPSC-MNs [39].