TARDBP and amyotrophic lateral sclerosis: We found that the formation of TDP-43 aggregates and the recruitment of TDP-43 into SGs occurred specifically in chronic stress conditions (10 μM SA 24 h) in UBQLN2P497H MNs (Figure 4C), which is very similar to the pathological inclusions observed in ALS/FTD brains, indicating that chronic oxidative stress could better mimic the neurodegenerative process.