Crocin, extracted from Crocus sativus L., protects against Bax/caspase-3-mediated apoptosis probably by downregulating GRP78 (an ERS marker) and CHOP expression in the prefrontal cortical neurons and also the hippocampal CA1 region at 14 days after Aβ25–35-induced AD [140]. Here, HSPA5 is linked to Alzheimer disease.