In 2020, Chen et al. reported that timosaponin BII, isolated from Anemarrhena asphodeloides Bunge, protects against cognitive impairment partly through the downregulation of TNF-α, IL-1β, and iNOS expression in the hippocampus at 38 days after LPS-induced inflammation and AD [75]. The gene discussed is NOS2; the disease is Alzheimer disease.