In 2016, Zong et al. reported that icariin, the main component from E. brevicornum Maxim, attenuates Aβ-induced caspase-3-apoptoic cascade and improves spatial learning mainly through the downregulation of NF-κB-, ERK1/2-, p38 MAPK-, and JNK-mediated signaling in the hippocampus at 20 days after IBO-induced AD [122]. Here, MAPK8 is linked to Alzheimer disease.