CASP3 and Alzheimer disease: In 2018, Wei et al. found that 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD), from Averrhoa carambola L., protects against Aβ-induced apoptosis mainly by increasing Bcl-2/Bax expression and suppressing cleaved caspase-9 and caspase-3 expression in the hippocampus at 21 days in APP/PS1 transgenic AD mice [133].