The pathological hallmarks of AD include the extracellular accumulation of amyloid β (Aβ) plaques; intracellular aggregation of hyperphosphorylated tau (p-tau), which subsequently forms neurofibrillary tangles (NFTs); and loss of cholinergic transmission in the layer II entorhinal cortex, hippocampus, and basal forebrain—resulting in cognitive dysfunction [14,17,18,19]. Here, MAPT is linked to Alzheimer disease.