A steroid-enriched fraction of Achyranthes bidentata protects against Aβ-induced inflammation partly through the downregulation of p38 MAPK/JNK/NF-κB-mediated signaling in the cortex and hippocampus at 16 days after Aβ1–40-induced AD [84]. The gene discussed is MAPK8; the disease is Alzheimer disease.