In 2019, Zhang et al. demonstrated that safflower yellow ameliorates Aβ-induced inflammation and cognitive decline mainly through the downregulation of TNF-α, IL-1β, and IL-6 expression and upregulation of Arg1 expression in the cortex and hippocampus at 20 days after Aβ1–42-induced AD [77]. This evidence concerns the gene IL6 and Alzheimer disease.