In 2016, Wang et al. reported that caffeic acid, extracted from Ocimum gratissimum, ameliorates Aβ-induced inflammation mainly by downregulating p38 MAPK/NF-κB-mediated signaling in the hippocampus at 2 weeks after Aβ1–40-induced AD [85]. This evidence concerns the gene NFKB1 and Alzheimer disease.