However, in 2019, Jiang et al. demonstrated that icariin protects from Aβ-induced apoptosis partly by downregulating Beclin-1, LC3-II/LC3-I, and cleaved caspase-3 expression in the hippocampus at 5 days after Aβ1–42-induced AD [144]. Here, CASP3 is linked to Alzheimer disease.