Ginsenoside Rg5, derived from P. ginseng, attenuates Aβ-induced inflammation and Aβ deposition mainly by upregulating BDNF and IGF-1 expression and downregulating TNF-α, IL-1β, iNOS, and COX-2 expression in the cortex and hippocampus at 28 days after STZ-induced AD [81]. Here, NOS2 is linked to Alzheimer disease.