Scutellarein, derived from Scutellaria baicalensis, effectively reduces Aβ-induced apoptosis mainly through the upregulation of Bcl-2 expression and downregulation of Bax and cleaved caspase-3 expression in the hippocampus at 28 days after Aβ-induced AD [134]. The gene discussed is CASP3; the disease is Alzheimer disease.