In this way, onco-miR-221 and AEG-1 clusters may regulate the apoptosis, cell cycle, angiogenesis, and autophagy regulatory proteins PI3K, Akt, p53, p57, Bcl-2, RB1, OPN, MMP9, and LSF in HCC. The gene discussed is TFCP2; the disease is hepatocellular carcinoma.