SKP2 and neoplasm: Wang et al. harvested early passage osteosarcoma cells from mice tumors to develop osteosarcoma organoids and proved that the inhibition of p27 degradation by S-Phase Kinase Associated Protein 2 (SKP2) significantly delays osteosarcoma development and progression, induces apoptosis, and diminishes tumor-initiating properties in the organoid model [33].