BRCA1 and cancer: Among patients presenting a positive family history of any cancer (n = 213), a total of 39 deleterious variants were detected in 38 patients, including BRCA1 (41.0%, 16/39), BRCA2 (35.9%, 14/39), PALB2 (5.1%, 2/39), TP53 (5.1%, 2/39), and other genes (12.8%, 5/39).