The panel-gene variant rate of HR-positive (any Her2 expression status) BC patients was 11.1% (52/469), and a total of 54 variants were detected in these patients, including BRCA2 (50%, 27/54), BRCA1 (18.5%, 10/54), PALB2 (11.1%, 6/54), NBN (5.6%, 3/54), and other genes (14.8%, 8/54). The gene discussed is ERBB2; the disease is breast cancer.