IL6 and Sepsis: Inflammation acts as a protective mechanism, but uncontrolled inflammation reactions may develop chronic diseases like sepsis, IBD, etc. LPS activates macrophages to initiate an inflammatory response to secrete pro-inflammatory cytokines such as tumor necrosis factor-α (TNFα), interferon-gamma (INFγ), interleukin 6 (IL-6), response to inflammation [43].