Moreover, the expression of GHRH and GHRH-Rs, including the splice variant 1 (SV1) of GHRH-R, has been shown in a variety of cancers, where GHRH acts as a growth factor through paracrine/autocrine-mediated mechanisms [11,12,13,14,15,16,17,18]. The gene discussed is GHRHR; the disease is cancer.