The cause of AD is unclear, but the loss of cholinergic neurotransmission [5], deposition of β-amyloid (Aβ) plaques [6], accumulation of hyperphosphorylated tau-protein [7], and increased oxidative stress [8] have been considered as the main inducing factors of AD, and various therapeutic approaches have been proposed. The gene discussed is MAPT; the disease is Alzheimer disease.