HMGB1 expression has been investigated in Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, multiple sclerosis, neuromyelitis optica, neuropathic pain, epilepsy, stroke, intracerebral hemorrhage, and traumatic brain injury (Table 1) [12,13,14,15]. Here, HMGB1 is linked to intracerebral hemorrhage.