COMTD1 and infection: For example, in LS, catechol O-methyltransferase domain-containing protein 1, Macrophage inflammatory protein 2-alpha, Matrix metalloproteinase-9, complement C1q-like protein 2 and MMP 13 (Supplementary Table S2) all showed 150-200-fold higher expression in the high-infection category, and they are all reported as bacteria-responding immune genes [36].