RELA and Keratoconjunctivitis sicca: Lee et al. [11] used ozone to induce a dry eye model and found that ozone led to corneal epithelial disruption and a decrease in the number of mucin-secreting cells, induced inflammatory cytokine production without altering tear volume and caused increased NF-κB p65 nuclear translocation, IκBα protein hydrolysis and phospho (p)-IκBα expression.