Considering that the distributions of methylation values obtained for metastasized primary tissues (M+) and metastatic tissue (Mtx) samples appeared to be similar, the question was raised as to whether this characteristic would also be found when CpG-site-specific methylation data are evaluated, and corresponding data for INA, NHLH2, and THBS4, which were previously identified to be statistically associated with RCC metastasis, are included. This evidence concerns the gene NHLH2 and renal cell carcinoma.