THBS4 and renal cell adenocarcinoma: Considering that the distributions of methylation values obtained for metastasized primary tissues (M+) and metastatic tissue (Mtx) samples appeared to be similar, the question was raised as to whether this characteristic would also be found when CpG-site-specific methylation data are evaluated, and corresponding data for INA, NHLH2, and THBS4, which were previously identified to be statistically associated with RCC metastasis, are included.