Obestatin attenuated histological damage in colitis by reducing the polymorphonuclear leukocyte infiltration (as evaluated by tissue MPO levels), inhibiting production of ROS and proinflammatory Th1 cytokines in both acute and chronic colitis, and stimulating the synthesis of anti-inflammatory cytokines in chronic colitis [115,117]. The gene discussed is MPO; the disease is Chronic colitis.