Overall, the main anti-inflammatory effects of the ghrelin included: lowered inflammation (especially in chronic colitis) on both the tissue and the systemic level, as well as disease relapse prevention [38,115], healing of colonic lesions in mucosa with spontaneous regeneration of the colon [39,107,142,143,144,145,146], maintenance of intestinal barrier function [143], improved blood flow and increased cell proliferation in mucosa [107,145], increased DNA synthesis in the colon mucosa [145], and protection of the intestinal mucosa from sepsis-related injury [32]. This evidence concerns the gene GHRL and Chronic colitis.