CDKN2A and atherosclerosis: To further unveil the role of LPS in the pathogenesis of atherosclerosis as a direct senescence-inducing/enhancing agent, in vivo association of LPS and senescent cells (e.g., the colocalization of labeled LPS and senescent cell markers such as SA-β-Gal or p16/INK4+) and the correlations with pathological changes should be analyzed in LPS-injected atherosclerotic mice.