IL6 and periodontitis: TNF-α, IL-1β, and IL-6 were increased in serum, and VCAM-1 and ICAM-1 were increased in the atherosclerotic plaques of ApoE KO periodontitis mice, accompanied by increased Oil-Red O-stained plaque areas of the aorta after the subgingival injection of LPS for 10 weeks [62].