IL1B and periodontitis: LPS from Campylobacter rectus, associated with adult periodontitis, induced the higher production of IL-6 and plasminogen activator in senescent gingival fibroblasts prepared by serial passage [99,100], while LPS increased the expression of IL-1α, IL-1β, IL-6, MCP-1, and PAI-2 in senescent adipocyte progenitors prepared with ionizing radiation relative to LPS-treated non-senescent cells [101].