In a randomized controlled clinical trial, 1 g RSV during a 3-month-long treatment significantly (p < 0.01) decreased the C-reactive protein (CRP) level in 100 rheumatoid arthritis (RA) patients, and the disease activity score assessing 28 joints erythrocyte sedimentation rate (DAS28-ESR), the erythrocyte sedimentation rate (ESR), the levels of interleukin-6 (IL-6), matrix metalloproteinase (MMP-3), rheumatoid factor (RF), tumor necrosis factor-alpha (TNF-α), undercarboxylated osteocalcin score (ucOC) were all highly significantly ameliorated (p < 0.001) [156]. Here, TNF is linked to rheumatoid arthritis.