In contrast, the knockdown of ZHX1 or PUMA reversed miR-199a-3p-mediated tumor inhibition roles, as determined by a mechanistic investigation, suggesting that the miR-199a-3p/ZHX1/PUMA signaling could be linked to BCL2, BCL2-associated X, and cleaved caspase 3. This evidence concerns the gene ZHX1 and neoplasm.