FOXN3 and neoplasm: More studies support the tumor-suppressive roles of ZHX1 in T-cell acute lymphoblastic leukemia (T-ALL), showing that ZHX1 was significantly reduced in T-ALL cells; moreover, other tumor suppressors, such as FOXN2 and FOXN3, were also concurrently downregulated in the T-ALL cell lines, in which both FOXN2 and FOXN3 formed a regulator network and directly activated the transcription of ZHX1 [35].