OTX1 and Hodgkins lymphoma: Lastly, the Hodgkin lymphoma cell lines that showed no expression of orthodenticle homeobox 1 and 2 (OTX1/2) (e.g., OTX 1 and 2 negative) overexpressed ZHX1, correlating with the genomic amplification of the 8q24 locus, supporting the oncogenic potential of ZHX1 in Hodgkin lymphoma [36].