Particularly for the angiogenesis (P00005) pathway, 11 miRNAs were detected, for the B cell activation (P00010) 10, for the Endothelin signaling pathway (P00019) 4, for the Gonadotropin-releasing hormone receptor pathway (P06664) 10, the Oxidative stress response (P00046) comprised 8, the p53 pathway feedback loops 2 (P04398) 9, the Alzheimer disease-amyloid secretase pathway (P00003) 10, and the PDGF signaling pathway (P00047) 9 (Figure 9). The gene discussed is GNRHR; the disease is early-onset autosomal dominant Alzheimer disease.