KRIT1 and famililal cerebral cavernous malformations: The KRIT1 (Krev interaction trapped 1) gene has been clearly associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a cerebrovascular disease affecting approximatively 0.5% of the population worldwide and characterized by the formation of abnormally enlarged and leaky capillary channels (caverns), which are referred to as CCM lesions.