The KRIT1 (Krev interaction trapped 1) gene has been clearly associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a cerebrovascular disease affecting approximatively 0.5% of the population worldwide and characterized by the formation of abnormally enlarged and leaky capillary channels (caverns), which are referred to as CCM lesions. Here, KRIT1 is linked to cerebral cavernous malformation.