KRIT1 and cerebral cavernous malformation: Interestingly, while providing novel insights into KRIT1 biological functions and consequent implications for new basic research avenues, our findings also raise the possibility that loss of KRIT1 heterozygous function mutations may predispose carriers not only to CCM disease, but also to metabolic comorbidities, thus, opening the door to novel perspectives for future preclinical and clinical studies.