KRIT1 and atherosclerosis: Recently, we reported that heterozygous KRIT1 knockout (KRIT1+/−) mice exposed to a high-fructose diet, known to induce systemic oxidative stress and inflammation, had an approximately 2-fold enhanced fat accumulation in the aortic arch and aortic root, as compared to corresponding wild-type (WT) littermates fed the same high-fructose diet, suggesting that KRIT1 may be implicated in intermediary metabolism–redox circuits underlying atherosclerosis development [25].