Of note, MA Rage−/− mice evidence a transcriptional drift of genes related to the regulation of cardiac cell growth and hypertrophy (Cluster 2B, Figure 6): some of them are positive regulators of cardiac hypertrophy, such as Edn1, while others, such as Ifngr2-Naftcs, mediate antihypertrophic effects (Table S2; [64,65]). Here, EDN1 is linked to cardiac hypertrophy.