Whole-body Stat6−/− mice show an abrogated expansion of tuft and goblet cells and compromised worm clearance after helminth infection, while IEC-specific STAT6 activation promotes the differentiation of tuft and goblet cells, and protects against helminths, indicating that epithelial STAT6 is necessary and sufficient to regulate tuft and goblet cell differentiation in IECs [6,11,12,13]. The gene discussed is STAT6; the disease is helminthiasis.