We report herein that ferroptosis is one of the major contributors to sorafenib-induced HCC cell death (Figure 1A–C), and that STAT3 inhibition by sorafenib plays a prominent role—via downregulation of MCL1 expression (Figure 4A) and facilitation of BECN1 binding to SLC7A11 (Figure 5A,B)—in sorafenib-triggered ferroptosis in HCC. The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.