In this respect, in the recent past, among other drugs [4,5,6,7,8,9,10,11,12], we have identified that the CGs OU and Digo prevent the proliferation of LumA cell lines modeling primary and metastatic BC by hyper-activating the 26S proteasome, which in turn determines the degradation of the ERα, the induction of the apoptotic cascade and, consequently, cell death [4]. The gene discussed is ESR1; the disease is breast cancer.