To tackle this issue and because different Na/K ATPase isoforms are expressed in different human tissues [16], we initially evaluated all the isoforms (i.e., ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, and ATP1B4) the mRNA expression levels in breast tumors and normal breast tissue by using the public available TNMplot database (https://tnmplot.com/analysis/ (accessed on 1 July 2022)) and used the RNAseq data [17]. This evidence concerns the gene ATP1A3 and breast neoplasm.