Therefore, the present results together with those previously reported [4] indicate that OU prevents the growth of cells modeling both LumA (i.e., MCF-7 and ZR-75-1 cells), LumB (i.e., BT-474 cells), and metastatic ET-resistant BC cells (i.e., MCF-7 Tam Res and expressing the Y537S receptor mutant). Here, TMEM43 is linked to breast cancer.