The leading anti-tumorigenic impact of individual effector molecules could be the inhibition of tumor growth/tumor cell proliferation [43,45], inhibition of tumor engraftment [46], promotion of DC development and maturation [41], recruitment of CD8+ T cells and their subsequent antigen-mediated activation [47], tumor cell cytotoxicity [48], or direct tumor cell clearance [49]. This evidence concerns the gene CD8A and neoplasm.