CD4 and neoplasm: Anti-tumorigenic activities in the tumor microenvironment can be mediated by IL12-producing tumor-infiltrating DCs, which promote CD8+ T cell responses [93]; MHC-I cross-dressed DCs presenting tumor antigens and allowing cross-priming to CD8+ T cells [94]; CD1d high-expressor DCs, which increase activation of NKT, CD4+ and CD8+ T cells [95]; or by cCD2s, which can promote control of cytotoxic T cell-resistant tumors via the CD4+ T cell-mediated activation of myeloid cells [96].