MMP9 and neuroblastoma: Female hormones emerged as effective triggers: estrogen activates MMP-2 and MMP-9 to increase beta amyloid degradation mediated through its ERα receptor subtype—at least in SH-SY5Y human neuroblastoma cells [242]-and Medroxyprogesterone Acetatea, a progestogen used in hormonal contraception suppresses amyloid-beta degradation in an MMP-9-dependent manner in vitro, and potentially compromises the clearance of β-amyloid in vivo [243].