NSD1 and erythroleukemia: However, alterations in NSD1 and NSD2 function have been linked to erythroleukemia development, a subtype of acute myeloid leukemia; indeed, it has been reported that NSD1 is a critical regulator of erythroid differentiation, since its knockdown impaired proper erythroblast maturation and induced erythroleukemia in mice [106].