NSD2 and plasma cell myeloma: In myeloma cells, H3K36 methylation is globally increased (in fact, NSD2 was first identified as MMSET—Multiple Myeloma SET domain protein—in human disease [48]), and consequently, its opposed mark, H3K27me3, decreases, leading to the aberrant activation of genes related to cellular adhesion, cell proliferation, and carcinogenesis [47,49,50,51].