Transmembrane-SR-PSOX/CXCL16 being a scavenger receptor for oxLDL [6,7,8,9] and obesity being directly associated with increased risk of atherothrombosis and thromboischemic complications, we further expanded our investigation to the influence of adipokines (adiponectin, adipsin, leptin, resistin) on platelet-CXCL16–CXCR6 axis in CAD patients. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.