In the current cohort of CAD patients, we observed a strong correlation between platelet-CXCL16 and platelet CXCR6 surface expression with indicators of basal platelet activation status, i.e., CD62P surface exposure denoting degranulation from α-granules (ρ = 0.284, p < 0.001 for platelet-CXCL16, and ρ = 0.321, p < 0.001 for CXCR6), and PAC-1 binding suggesting α2bβ3-integrin activation (ρ = 0.276, p < 0.001 for platelet-CXCL16, and ρ = 0.279, p < 0.001 for CXCR6) (Figure 2A,B). Here, SELP is linked to coronary artery disorder.