PPARGC1A and Parkinson disease: M30 [5-(N-methyl-N-propargyl-amino-methyl)-8-hydroxyquinone], a MAO inhibitor with iron-chelating activity, targets Sirt1/PGC-1α pathway and restores activity of DA neurons in animal PD models prepared with MPTP, lactocystin, and 6-OHDA [139].