LGMN and neoplasm: Since MMP-2 has been implicated in proper islet morphogenesis [62,63] and suggested as a marker for newly formed beta cells [11], and in light of the roles of Lgmn and Etv5 in tumor invasiveness and metastasis [64,65], it is possible that these factors may be involved in the assembly of newly formed islets by facilitating the migration of endocrine (precursor) cells [66].