When EVs isolated from BALF of fibrotic lungs (F-EVs) were re-instilled intratracheally into the BLM-fibrosis-mouse model (WT and Sdc1−/−), they showed that F-EVs exacerbated lung fibrosis in the WT-BLM-mouse model in comparison with Sdc1−/− animals. This evidence concerns the gene SDC1 and Bloom syndrome.