ADAM10 and fragile X syndrome: Moreover, increased mature ADAM10 has been shown to dysregulate APP cleavage to induce synaptic dysfunction in mice, deficient in the Fragile X mental retardation protein (FMRP) that leads to Fragile X syndrome and ASD-like behaviors [42]; this supports the present findings that ADAM10 maturation was increased in in utero VPA-exposed male mice brain.