in addition to baicalin and baicalin-based nanoparticles, it has been reported that baicalein not only directly targeted breast cancer cells but also inhibited MDA-MB-231 and MCF-7 breast cancer cell growth via promoting repolarization of M2-TAM to M1 phenotype and attenuating TGF-β1 secretion [73]. This evidence concerns the gene TGFB1 and breast cancer.