A recent study suggested that wogonin increases the expression of p53 and p53-induced regulators of glycolysis and apoptosis and then by modulating p53-downstream glucose transporter 1 (GLUT1) and some key glycolytic enzymes such as Primary gastric melanoma (PGM), Hexokinase 2 (HK2) and phosphorylate pyruvate dehydrogenase kinase 1 (PDHK1), wogonin inhibits glycolysis in cancer cells and ultimately exert anti-cancer effect. This evidence concerns the gene PDK1 and cancer.