For individual flavonoid in SR, by using an orthotopic hepatocellular carcinoma implantation mouse model, Tan et al. found that, mechanistically, baicalin initiated autophagic degradation of TRAF2 in TAMs and activated the p52 pathway, which thereby induced the polarization of M1-like macrophages and halted HCC development by remodeling the immunosuppressive TME [96]. Here, TRAF2 is linked to hepatocellular carcinoma.