Additionally, curcumin could prevent Alzheimer’s disease progression by reducing β-amyloid (Aβ) production and induce autophagy by downregulating the PI3K/AKT/mTOR signaling pathway in amyloid β precursor protein (APP)/presenilin 1 (PS1) double transgenic mice [40]. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.