S100A8 and hepatocellular carcinoma: The central regulator of pro-inflammatory pathways Nuclear Factor kappa B (NF-κB) was also shown to induce S100A6 expression in cardiac myocytes isolated from Sprague–Dawley rats [63], as well as S100A8 and S100A9 expression in Hep3B and Huh-7 HCC cell lines [45].