Deregulated mRNA expression of many S100 isoforms, i.e., S100P, S100A2, S100A5, S100A6, S100A7, S100A7A, S100A8, S100A9, S100A10, S100A11, S100A12, S100A13, S100A14, S100G and S100Z, has indeed been associated with HCC in patients [144]. The gene discussed is S100A11; the disease is hepatocellular carcinoma.