Further supporting the importance of S100 specific members in cell motility and cancer metastasis, matrix metalloproteinase (MMP) expression/activity and degradation of the extra-cellular matrix (ECM) is also under the control of S100 proteins such as S100A4, S100A8, S100A9, S100A10 and S100A14 [95,96,97,98]. The gene discussed is S100A10; the disease is cancer.