Deregulated mRNA expression of many S100 isoforms, i.e., S100P, S100A2, S100A5, S100A6, S100A7, S100A7A, S100A8, S100A9, S100A10, S100A11, S100A12, S100A13, S100A14, S100G and S100Z, has indeed been associated with HCC in patients [144]. Here, S100A8 is linked to hepatocellular carcinoma.