CD274 and lung carcinoma: After treatment with 5-Aza, the PD1 expression was significantly increased in eight lung cancer cell lines (H2170, H1299, H226, H157, H23, A549, H1650, and H1975), and PD-L1 expression was significantly enhanced in nine lung cancer cell lines (H2170, H1299, H226, H157, H2030, COLO677, A549, H1650, and H1975) (Supplementary Figure S1).