TP53 and cancer: Researchers have studied aggrephagy as a target in p53-expressing cancer cells in works using different approaches, such as the colocalization of protein aggregates with LC3-II or p62 protein as an aggrephagy marker [145]; the knockdown or inhibition of autophagy-related proteins to test whether p53 aggregates are no longer degraded [152]; and the coimmunoprecipitation of p53 protein aggregates with autophagy-related proteins to investigate whether the interaction between these proteins is reduced as autophagy increases, suggesting their degradation [153].