TP53 and lung cancer: p53 aggregates formed by mutp53 (R282W) promote chemoresistance to cisplatin in lung cancer cells by activating the unfolded protein response (UPR) and upregulating endoplasmic reticulum protein 29 (ERp29) [51], which can be a marker of endoplasmic reticulum stress, impairing protein folding, trafficking, and secretion [52].