TP53 and oral cavity squamous cell carcinoma: Yang-Hartwich et al. (2015) [40], showed that both in vitro and in vivo OCSC experimental models expressing wtp53 demonstrated a curious mechanism in which p14ARF, a p53-positive regulator, inhibited MDM2-mediated p53 degradation, triggering an imbalance of p53 turnover, wtp53 aggregation, and resistance to carboplatin [40].