CAMKK2 and bipolar disorder: In addition to an exonic variant, Thr85Ser (rs3817190), in human CaMKKβ/2 associated with behavioral disorders such as anxiety [94], a de novo mutation encoding Arg311Cys, which reduces the CaMKKβ/2 catalytic activity and its apparent affinity for Ca2+/CaM [74], was identified in bipolar disorder [141].