Autophosphorylation of Thr85 in human CaMKKβ/2 induces its autonomous activity, which is disrupted by a T85S mutation [93], an exonic single nucleotide polymorphism (SNP) (rs3817190) in the CaMKKβ/2 gene linked to anxiety and bipolar disorder [94]. Here, CAMKK2 is linked to Anxiety.