In KEGG pathway analysis, we observe that there are critical pathways that are well-known to be directly regulating CRC and these pathways are colorectal cancer pathway, pathways in cancer, endometrial cancer, prostate cancer, basal cell carcinoma, melanogenesis, bladder cancer, pancreatic cancer, non-small cell lung cancer, small cell lung cancer, glioma, acute myeloid leukemia, cell cycle, Wnt signaling, ErbB signaling, p53 signaling, cytokine and chemokine signaling, VEGF signaling, JAK-STAT signaling, apoptosis, and the major immune signaling pathways (Supplementary Table S1). This evidence concerns the gene TP53 and cancer.