In GC, ADAMTS16 mRNA expression was significantly correlated with age (p = 0.004), invasion depth (p = 0.013), lymph node metastasis (p = 0.042), distance metastasis stage (p = 0.004), and TNM stage (p = 0.011). This evidence concerns the gene ADAMTS16 and metastatic malignant neoplasm in the lymph nodes.