An intrachromosomal CIC-LEUTX fusion was detected in angiosarcoma [47], and in ARMS, it was demonstrated that PAX3-FOXO1 depends on BRD4 to drive the expression of its target oncogenes and that BRD4 inhibition leads to significant tumor suppression, ablating the transcription-driving function of the fusion gene [48]. This evidence concerns the gene FOXO1 and alveolar rhabdomyosarcoma.