TOM1L2 and osteosarcoma: For example, both fusion partners of the COPS3-TOM1L2 fusion transcript have been described to be frequently amplified in osteosarcoma [32,33], and TOM1L2 is involved in a recurrently detected rearrangement (TOM1L2-BRAF) in myxoinflammatory fibroblastic sarcomas [34].