LEPR and obesity due to melanocortin 4 receptor deficiency: Setmelanotide (Imcivree) is a melanocortin-4 (MC4) receptor agonist used for the treatment of obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/keying type 1 (PCSK1), or leptin receptor (LEPR) deficiency.